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CHAPTER 2

Getting the right diagnosis

Discover how doctors identify IgG4-RD using blood tests, imaging, biopsies, and clinical patterns.

7 lessons
Total: TBC
Current lesson
Chapter 2: Quiz
A short quiz to check your understanding of how IgG4‑RD is diagnosed.
5 minutes
Chapter 2 Lessons
Chapter 2 introduction
Learn about the tools doctors use to diagnose IgG4-RD including medical history, tests, and observation.
2 minutes
Diagnosis overview
Why IgG4-RD is often missed, and clues to diagnosis.
8 minutes + videos
Classification criteria
Why formal criteria exist, and how they affect diagnosis.
8 minutes + video
Blood tests
Blood tests can guide care, but are not the whole story.
8 minutes + video
Imaging
Imaging helps spot silent organ involvement and guides biopsy.
6 minutes + videos
Biopsy
Biopsies clarify diagnosis by excluding alternative causes.
10 minutes + video
Chapter 2: Quiz
A short quiz to check your understanding of how IgG4‑RD is diagnosed.
5 minutes
Go to Treatment and disease management
Treatment and disease management

Chapter 2: Quiz

Test Your Knowledge

Congratulations for taking the time to review all of the lessons in this Chapter. Now, let’s test your knowledge. Pick the best answer for each question to test your state of knowledge.

Ready to take the quiz? Start
1 of 8
True or false: A person must meet the ACR/EULAR classification criteria to bediagnosed with IgG4‑RD.
True
False
Please select an answer.
Back Continue
2 of 8
Which of the following is not a red flag that would push doctors to look for another diagnosis instead of IgG4-RD?
Granulomas on pathology
Necrotizing vasculitis
Prominent neutrophils or necrosis on pathology
Malignant-appearing lymphocytes
Storiform fibrosis in biopsy
Please select an answer.
Back Continue
3 of 8
True or false: A very high IgG4 level proves that I have active IgG4‑RD.
True
False
Please select an answer.
Back Continue
4 of 8
Which is the better approach?
reacting to a single abnormal lab
looking for agreement among symptoms, imaging, and lab trends
Please select an answer.
Back Continue
5 of 8
Which statement is most accurate?
PET/CT scans usually establish the diagnosis of IgG4‑RD clearly.
CT/MRI/PET guide care but usually need biopsy confirmation.
MRI is seldom useful in the evaluation of head and neck disease.
Please select an answer.
Back Continue
6 of 8
Why might your doctor order CT scans of the chest, abdomen, and pelvis even if your symptoms are only in the head and neck?
To reduce costs compared with MRI
Because head and neck symptoms always mean lung disease
To look for silent involvement in other organs that could change treatment
To avoid needing a biopsy in all cases
Please select an answer.
Back Continue
7 of 8
Why are IgG4-positive plasma cells alone not sufficient to diagnose IgG4-related disease?
Because IgG4-positive plasma cells are only found in the blood, not in tissues
Because elevated IgG4-positive plasma cells can also be seen in other diseases
Because plasma cells are not involved in IgG4-related disease
Because IgG4 staining is unreliable and should not be used
Please select an answer.
Back Continue
8 of 8
True or False: A biopsy can help protect patients from unnecessary or potentially toxic treatments by ruling out diseases that IgG4-RD mimics.
True
False
Please select an answer.
Back Continue
Your Score:
1 of 8
True or false: A person must meet the ACR/EULAR classification criteria to bediagnosed with IgG4‑RD.
True
False
2 of 8
Which of the following is not a red flag that would push doctors to look for another diagnosis instead of IgG4-RD?
Granulomas on pathology
Necrotizing vasculitis
Prominent neutrophils or necrosis on pathology
Malignant-appearing lymphocytes
Storiform fibrosis in biopsy
3 of 8
True or false: A very high IgG4 level proves that I have active IgG4‑RD.
True
False
4 of 8
Which is the better approach?
reacting to a single abnormal lab
looking for agreement among symptoms, imaging, and lab trends
5 of 8
Which statement is most accurate?
PET/CT scans usually establish the diagnosis of IgG4‑RD clearly.
CT/MRI/PET guide care but usually need biopsy confirmation.
MRI is seldom useful in the evaluation of head and neck disease.
6 of 8
Why might your doctor order CT scans of the chest, abdomen, and pelvis even if your symptoms are only in the head and neck?
To reduce costs compared with MRI
Because head and neck symptoms always mean lung disease
To look for silent involvement in other organs that could change treatment
To avoid needing a biopsy in all cases
7 of 8
Why are IgG4-positive plasma cells alone not sufficient to diagnose IgG4-related disease?
Because IgG4-positive plasma cells are only found in the blood, not in tissues
Because elevated IgG4-positive plasma cells can also be seen in other diseases
Because plasma cells are not involved in IgG4-related disease
Because IgG4 staining is unreliable and should not be used
8 of 8
True or False: A biopsy can help protect patients from unnecessary or potentially toxic treatments by ruling out diseases that IgG4-RD mimics.
True
False
Retry
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