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CHAPTER 1
Understanding the disease
What IgG4-related disease is, why it can look like many other conditions, and how it affects the body.
8 lessons
Total: TBCCurrent lesson
Chapter 1: Quiz
Test your knowledge of IgG4-related disease.
5 minutesChapter 1: Quiz
Test your knowledge
Congratulations for taking the time to review all of the lessons in this Chapter. Now, let’s test your knowledge. Pick the best answer for each question to see how much you know.
Ready to take the quiz?
Start
1 of 12
True or False: IgG4‑RD can affect many organs and often causes mass‑like swelling due to inflammation and fibrosis.
True
False
Please select an answer.
2 of 12
Which tissue pattern best fits IgG4-related disease?
Pockets of pus and a special type of dead tissue (caseating granulomas)
A dense mix of lymphocytes and plasma cells, swirled scar tissue (storiform fibrosis), and veins that are destroyed by the inflammatory infiltrate (obliterative phlebitis)
Only eosinophils with no scar tissue
Signs of a virus inside cells
Please select an answer.
3 of 12
The modern term “IgG4‑related disease” became established in the:
1980s
1990s
2000s
2020s
Please select an answer.
4 of 12
True or False: The earliest clinical descriptions of a patient who would be diagnosed today with IgG4 came from Europe.
True
False
Please select an answer.
5 of 12
Which statement about the IgG4 molecule is most accurate?
It strongly activates complement
It often acts in a calming/anti ‑ inflammatory way and can undergo Fab‑ arm exchange
It is the most abundant IgG subclass in blood
It is a cytokine
Please select an answer.
6 of 12
True or False: There is only one kind of IgG, and IgG4 is the same as IgG.
True
False
Please select an answer.
7 of 12
Circulating plasmablasts in IgG4‑RD are best described as:
CD19−, CD20+
CD19+, CD20−
CD3+, CD4+
CD56+, CD16+
Please select an answer.
8 of 12
True or False: B‑ cell–targeted therapies aim to reduce B‑ cell activation or numbers and can help limit fibrosis over time.
True
False
Please select an answer.
9 of 12
True or False: Fibroblasts only create harmful scar tissue and never help with healing.
True
False
Please select an answer.
10 of 12
Which cell type most directly links allergy and IgG4‑RD symptoms in some patients?
Neutrophils
Eosinophils
Red blood cells
Platelets
Please select an answer.
11 of 12
True or False: A high blood IgG4 level by itself proves that someone has IgG4‑RD.
True
False
Please select an answer.
12 of 12
Which one is most accurate? In IgG4‑RD, fibrosis can:
Only happen in the pancreas
Be found in many different organs and sometimes narrow tubes like bile ducts or ureters
Always go away completely with steroids
Please select an answer.
Your Score:
1 of 12
True or False: IgG4‑RD can affect many organs and often causes mass‑like swelling due to inflammation and fibrosis.
True
False
2 of 12
Which tissue pattern best fits IgG4-related disease?
Pockets of pus and a special type of dead tissue (caseating granulomas)
A dense mix of lymphocytes and plasma cells, swirled scar tissue (storiform fibrosis), and veins that are destroyed by the inflammatory infiltrate (obliterative phlebitis)
Only eosinophils with no scar tissue
Signs of a virus inside cells
3 of 12
The modern term “IgG4‑related disease” became established in the:
1980s
1990s
2000s
2020s
4 of 12
True or False: The earliest clinical descriptions of a patient who would be diagnosed today with IgG4 came from Europe.
True
False
5 of 12
Which statement about the IgG4 molecule is most accurate?
It strongly activates complement
It often acts in a calming/anti ‑ inflammatory way and can undergo Fab‑ arm exchange
It is the most abundant IgG subclass in blood
It is a cytokine
6 of 12
True or False: There is only one kind of IgG, and IgG4 is the same as IgG.
True
False
7 of 12
Circulating plasmablasts in IgG4‑RD are best described as:
CD19−, CD20+
CD19+, CD20−
CD3+, CD4+
CD56+, CD16+
8 of 12
True or False: B‑ cell–targeted therapies aim to reduce B‑ cell activation or numbers and can help limit fibrosis over time.
True
False
9 of 12
True or False: Fibroblasts only create harmful scar tissue and never help with healing.
True
False
10 of 12
Which cell type most directly links allergy and IgG4‑RD symptoms in some patients?
Neutrophils
Eosinophils
Red blood cells
Platelets
11 of 12
True or False: A high blood IgG4 level by itself proves that someone has IgG4‑RD.
True
False
12 of 12
Which one is most accurate? In IgG4‑RD, fibrosis can:
Only happen in the pancreas
Be found in many different organs and sometimes narrow tubes like bile ducts or ureters
Always go away completely with steroids
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